RCT DUPLICATE
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RCT DUPLICATE

Randomized Controlled Trials Duplicated Using Prospective Longitudinal Insurance Claims:
Applying Techniques of Epidemiology

Our Work

Our Team

Our Impact

We are building an empirical evidence base for real world data through large-scale replication of randomized controlled trials. Our goal is to understand for what types of clinical questions real world data analyses can be conducted with confidence and with which designs and analysis methods.   
The core research team is within the Division of Pharmacoepidemiology and Pharmacoeconomics at the Brigham and Women's Hospital. We collaborate closely with colleagues at FDA and at Aetion, Inc. Our expert advisory board includes top experts in design and analysis methods for nonrandomized studies as well as randomized trials.
If principled nonrandomized study approaches based on healthcare databases can consistently match the results of published trials and predict the results of ongoing trials, then we gain confidence in the validity of future real world data analyses that may be performed in the absence of randomized trial evidence. 
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  • Home
  • People
    • Core Team
    • Expert Advisory Panel
    • Collaborators
  • Projects
    • FDA Demonstration Project
    • FDA Prediction Project
    • NHLBI Grant
    • Other Prospective Projects
  • Publications
  • Project Updates
  • Contact Us